Mechanism-Based Toxicology in Cancer Risk Assessment: Implications for Research, Regulation, and Legislation

Abstract

Research ArticleOpen AccessMechanism-based toxicology in cancer risk assessment: implications for research, regulation, and legislation. G W Lucier G W Lucier National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Search for more papers by this author Published:1 January 1996https://doi.org/10.1289/ehp.9610484Cited by:11AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited By Abraham J and Ballinger R (2012) The emergence of the genetically engineered animal models in carcinogenic risk assessment of pharmaceuticals: a case study of process innovation, New Genetics and Society, 10.1080/14636778.2012.662025, 31:2, (223-247), Online publication date: 1-Jun-2012. Wolfe M and Portier C (2006) National Toxicology Program Toxicology and Regulatory Process, 10.1201/b14106-7, (129-160), Online publication date: 3-Mar-2006. Ji Z, Zhao W, Liao G, Choi R, Lo C, Dong T and Tsim K (2009) In vitro estrogenic activity of formononetin by two bioassay systems , Gynecological Endocrinology, 10.1080/09513590600924345, 22:10, (578-584), Online publication date: 1-Jan-2006. Chhabra R, Bucher J, Wolfe M and Portier C (2003) Toxicity characterization of environmental chemicals by the US National Toxicology Program: an overview, International Journal of Hygiene and Environmental Health, 10.1078/1438-4639-00240, 206:4-5, (437-445), Online publication date: 1-Jan-2003. Portier C (2001) Linking toxicology and epidemiology: the role of mechanistic modelling, Statistics in Medicine, 10.1002/sim.676, 20:9-10, (1387-1393), Online publication date: 15-May-2001. Greaves P (2000) Haemopoietic and Lymphatic Systems Histopathology of Preclinical Toxicity Studies, 10.1016/B978-044450514-9/50003-6, (87-156), . Eastin W, Haseman J, Mahler J and Bucher J (2016) The National Toxicology Program Evaluation of Genetically Altered Mice as Predictive Models for Identifying Carcinogens, Toxicologic Pathology, 10.1177/019262339802600401, 26:4, (461-473), Online publication date: 1-Jul-1998. Lucier G and Barrett J (1998) Public health policy and the National Toxicology Program., Environmental Health Perspectives, 106:10, (A470-A471), Online publication date: 1-Oct-1998.Eastin W (2018) The U.S. National Toxicology Program evaluation of transgenic mice as predictive models for identifying carcinogens., Environmental Health Perspectives, 106:suppl 1, (81-84), Online publication date: 1-Feb-1998.Bucher J and Lucier G (2018) Current approaches toward chemical mixture studies at the National Institute of Environmental Health Sciences and the U.S. National Toxicology Program., Environmental Health Perspectives, 106:suppl 6, (1295-1298), Online publication date: 1-Dec-1998.Huff J, Weisburger E and Fung V (2018) Multicomponent criteria for predicting carcinogenicity: dataset of 30 NTP chemicals., Environmental Health Perspectives, 104:suppl 5, (1105-1112), Online publication date: 1-Oct-1996. Vol. 104, No. 1 January 1996Metrics About Article Metrics Publication History Originally published1 January 1996Published in print1 January 1996 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.