Abstract
Polymethyl methacrylate (PMMA) bone cement is a commonly used bone adhesive and filling material in percutaneous vertebroplasty and percutaneous kyphoplasty surgeries. However, PMMA bone cements have been reported to cause some severe complications, such as secondary fracture of adjacent vertebral bodies, and loosening or even dislodgement of the set PMMA bone cement, due to the over-high elastic modulus and poor osteointegration ability of the PMMA. In this study, mineralized collagen (MC) with biomimetic microstructure and good osteogenic activity was added to commercially available PMMA bone cement products, in order to improve both the mechanical properties and the cytocompatibility. As the compressive strength of the modified bone cements remained well, the compressive elastic modulus could be significantly down-regulated by the MC, so as to reduce the pressure on the adjacent vertebral bodies. Meanwhile, the adhesion and proliferation of pre-osteoblasts on the modified bone cements were improved compared with cells on those unmodified, such result is beneficial for a good osteointegration formation between the bone cement and the host bone tissue in clinical applications. Moreover, the modification of the PMMA bone cements by adding MC did not significantly influence the injectability and processing times of the cement.
Highlights
Vertebral compression fractures (VCF) are one of the most common fractures for the elders with osteoporosis
The results indicates that the modification of Polymethyl methacrylate (PMMA) bone cements by addition of mineralized collagen (MC) could improve its cytocompatibility, which is beneficial for the formation of good osteointegration between the bone cement and the host bone in clinical applications
Bioinert is another disadvantage of the PMMA bone cement, since osteocytes cannot grow into the bioinert PMMA, it is unable to form stable osteointegration between the bone cement and the host bone at the implant site [13,14,15]
Summary
Vertebral compression fractures (VCF) are one of the most common fractures for the elders with osteoporosis. In the United States, it was reported that about 25% of postmenopausal women suffered from VCF, and such morbidity rate was estimated to be 40% for those women over 80 years old [1]. With the current accelerated trend of the aging of the world population, the occurrence of VCF will continue increasing. VCF can be induced by other disease, such as osteogenesis imperfecta [2], spinal tumors [3], and so on. Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are the major applications of the polymethyl methacrylate (PMMA) bone cement in the treatment of VCF. In either PVP or PKP, the bone cement is injected into the vertebral body for the augmentation of the fractured vertebral body
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