Abstract
T cell is one of the main player of mammalian immune response. It ensures antigen recognition at the surface of antigen presenting cells (APCs) in a complex highly sensitive and specific process where encounter of T cell receptor with agonist peptide associated with major histocompatibility complex triggers T cell activation. Despite its central role, the mechanism of TCR triggering is still unclear. Several models involving receptor oligomerisation, kinetic proofreading, serial triggering are currently under debate.We present here a work aimed to explore experimentally the role of mechanical cues in T cell activation.We will show the first results of mechanical engagement of TCR in Jurkat cell line using magnetic particles and related cell response as reported by intracellular Ca2+ transient.We will discuss then how these results could provide a mechanistic solution to the TCR triggering puzzle.View Large Image | View Hi-Res Image | Download PowerPoint Slide
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