Abstract
In this review paper, we theoretically explain the origin of electrostatic interactions between lipid bilayers and charged solid surfaces using a statistical mechanics approach, where the orientational degree of freedom of lipid head groups and the orientational ordering of the water dipoles are considered. Within the modified Langevin Poisson–Boltzmann model of an electric double layer, we derived an analytical expression for the osmotic pressure between the planar zwitterionic lipid bilayer and charged solid planar surface. We also show that the electrostatic interaction between the zwitterionic lipid head groups of the proximal leaflet and the negatively charged solid surface is accompanied with a more perpendicular average orientation of the lipid head-groups. We further highlight the important role of the surfaces’ nanostructured topography in their interactions with biological material. As an example of nanostructured surfaces, we describe the synthesis of TiO2 nanotubular and octahedral surfaces by using the electrochemical anodization method and hydrothermal method, respectively. The physical and chemical properties of these nanostructured surfaces are described in order to elucidate the influence of the surface topography and other physical properties on the behavior of human cells adhered to TiO2 nanostructured surfaces. In the last part of the paper, we theoretically explain the interplay of elastic and adhesive contributions to the adsorption of lipid vesicles on the solid surfaces. We show the numerically predicted shapes of adhered lipid vesicles corresponding to the minimum of the membrane free energy to describe the influence of the vesicle size, bending modulus, and adhesion strength on the adhesion of lipid vesicles on solid charged surfaces.
Highlights
Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, 1000 Ljubljana, Slovenia; Department of Surface Engineering and Optoelectronics, Jožef Stefan Institute, 1000 Ljubljana, Slovenia; Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, 1000 Ljubljana, Laboratory of Clinical Biophysics, Chair of Orthopaedics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
NPs interacting with membranes may in possible interaction of NPs witheither the membrane is the attachment thatAnother results in pore formation, transient or permanent; the pore of the former on the membrane surface [34,38,40], encapsulation [30], or their intercalation lized by NPs
We shall start with a short description of the modified Langevin Poisson–Boltzmann (LPB) model of the electric double layer [38,125,126], which presents the generalization of classic Poisson–Boltzmann (PB) theory for point-like ions by taking into account the orientational ordering of water molecules in an EDL
Summary
The shape and biological functions of membranes can be strongly influenced by atThe shape and biological functions of membranes can be strongly influenced by tached,. NPs interacting with membranes may in possible interaction of NPs witheither the membrane is the attachment (adsorption) thatAnother results in pore formation, transient or permanent; the pore of the former on the membrane surface [34,38,40], encapsulation [30], or their intercalation lized by NPs. Nanoparticles could cluster within membran in the membrane [41,42,43]. The resulting configuration could be driven by the the NP shape, charge, size,in and stiffness; it depends on the nature of the NP–membraneinfluence interacchange the membrane mechanics could significantly its tion [30,34,38,39,41,44]. Nanoparticles could cluster within the membrane, and the resulting change in the membrane mechanicsof could significantly influence its biologicalSurfaces function and could even
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