Abstract
Background Expansion of myocardial extracellular volume (ECV) as detected by native and post contrast T1 mapping has been associated with different types of cardiomyopathy. We hypothesize that fully quantitative evaluation of MR perfusion imaging can localize and quantify edematous ECV expansion after acute coronary events with sensitivity equivalent to ECV measurements based on T1 mapping or the detection of corresponding inflammatory and metabolic processes with FDG-PET.
Highlights
Expansion of myocardial extracellular volume (ECV) as detected by native and post contrast T1 mapping has been associated with different types of cardiomyopathy
Sector wise ECV measurements based on T1 mapping and perfusion modeling correlated (R2=0.85) while perfusion imaging overestimated ECV by a constant 5.4% compared to T1 mapping
Myocardial plasma flow showed no correlation with ECV from T1 mapping (R2=-0.15)
Summary
Measuring the expansion of myocardial extracellular volume using quantitative perfusion imaging: Validation with T1 mapping and simultaneous 18FDG-PET in patients after acute myocardial infarction. Karl P Kunze*, Christoph Rischpler, Sylvia Schachoff, Markus Schwaiger, Stephan G Nekolla
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