Abstract
Rapid, sensitive separation and determination of tryptophan, N′-for-mylkynurenine, kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, nicotinic acid, nicotinamide, trigonelline, kynurenic acid, and xanthurenic acid in untreated and extracted urine were achieved using reverse-phase high-pressure liquid chromatography. Accuracy of the measurements is 5% or better and 50 pmole of each compound can be reliably measured. Determination of quinolinic acid was not possible with the conditions used. The method was found to be suitable for the analysis of urinary metabolites in a normal human subject under basal conditions and after tryptophan loading.
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