Measurement of tidal respiration in

Abstract

Objective To investigate pulmonary function in terms of tidal respiration and the influencing factors on it in <34 weeks premature infants with RDS at corrected gestational age of 40 weeks. Methods A total of 49 of <34 weeks premature infants with RDS (RDS group) and 36 of <34 weeks premature infants without RDS (non-RDS group) followed throughout entire twelve months were collected from December 2013 to October 2015.Of them, 35 RDS patients and 20 non-RDS patients had the pulmonary function examination .A total of 26 full term infants with hyperbilirubinemia (full term group) were recruited for comparison study. The differences in parameters of tidal respiration were compared among the three groups. The RDS patients were further divided into the mild RDS subgroup and severe RDS subgroup according to the severity of illness. Result ①The TPEF [(0.17±0.04)s vs.(0.23±0.09)s], VPEF [(6.74±2.70)mL vs.(9.33±2.92)mL], TPEF/TE [(29.06±4.21)% vs. (38.27±7.16)%], VPEF/VE [(32.54±4.43)% vs. (39.64±5.88)%] in RDS group were significantly lower than those in full term group (P 0.05). ②The TPEF, VPEF, TPEF/TE, VPEF/VE in mild RDS group were higher than those in severe RDS group, but the differences were not significant (P>0.05). ③Logistic regression analysis indicated that the gestational age was the protective factor of pulmonary function in premature infants with RDS. Conclusions Small airway resistance in <34 weeks premature infants with RDS is higher than that in full term infants. There was no significant difference in pulmonary function between RDS premature infants and non-RDS premature infants. The gestational age was the influencing factor of pulmonary function in premature infants with RDS. Key words: Respiratory distress syndrome; Premature infant; Full term infant; Newborn; Tidal respiration pulmonary function; Mild; Severe; Influencing factors