Measurement of the Three-Dimensional Muscle Endpoint Forces in the Extended Thumb and Its Application to Determining Muscle Combinations that Enable Lateral Pinch Force Production Throughout the Plane of Flexion-Extension.

Abstract

Functional outcomes of tendon transfer surgeries, designed to restore lateral pinch grasp to persons following cervical spinal cord injury, have been mixed. That is, pinch force magnitudes have varied by 10-fold and have been reported to be as low as low as tenths of a pound. We believe a novel tendon transfer approach in which the donor muscle actuates a small group of paralyzed thumb muscles, instead of just the flexor pollicis longus (FPL) muscle (the current approach), will enable endpoint forces that are better directed and therefore a consistently stronger pinch force following surgery. We further believe that such surgeries can be better designed to account for grasp force production throughout the entire plane of flexion-extension if muscle endpoint forces in the extended thumb are known. Consequently, we measured muscle endpoint forces in the extended thumb in 6 cadaveric specimens after a force of 10 N was applied to each muscle. Further, we simulated a tendon transfer surgery in which the donor muscle applied equal force to each muscle in 246 small groups of muscles, calculated the direction of the resulting endpoint force throughout the flexion-extension plane, and determined if those groups of muscles produced a better directed force than FPL's. While we found that 3 individual muscles and 52 muscle groups could produce desirably directed endpoint forces in parts of the flexion-extension plane, no muscle or muscle group could produce well-directed endpoint forces throughout the flexion-extension plane. We concluded that a group of muscles could likely be found if the donor muscle provided different levels of force to each of the muscles in a muscle group. This would be possible through intentional geometric manipulation of the donor-to-recipient muscle attachment to allow for unequal splitting of donor muscle force.Clinical Relevance-This work aims to determine whether the same combination of thumb muscles can produce well-directed endpoint forces throughout the flexion-extension plane. If so, then this work informs surgeons which muscle groups could be involved in a tendon transfer to restore lateral pinch grasp ability throughout the plane of flexion-extension in person with cervical spinal cord injury.