Abstract
Hypercoagulable states can be detected by measuring activation peptides, enzyme-inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction patients ( n=30 in each group) as well as in hematologic malignancies n=42 . The parameters assayed were: prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complexes (TAT), fibrinopeptide A (FPA), plasmin-α 2 antiplasmin complexes (PAP) and D-Dimer. Results were compared with those obtained in a group of 30 healthy subjects. We found a significant increase of F1+2, TAT and FPA in elderly ( p<0.05), acute myocardial infarction (AMI) ( p<0.01), hematologic malignancies ( p<0.01), and pregnancy ( p<0.0001), indicating a marked clotting activation. Diabetic patients under strict metabolic control only presented a moderate increase of TAT ( p<0.05), suggesting a slight activation. We also observed a highly significant elevation of PAP and D-Dimer in elderly ( p<0.001), AMI ( p<0.0001), and malignancy ( p<0.0001), indicating an activation of the fibrinolytic system. The combination of selected fibrinolytic and coagulation measurements is useful for the detection of a hypercoagulable state in conditions character- ized by a risk of thrombosis.
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