Abstract
The author reports measurement of the optical attenuation of the urinary bladder using Optical Coherence Tomography. This method uses the exponential relationship that exists between the intensity of the back-scattered infrared light and the penetration depth. The method is applied to Optical Coherence Tomography images of the human urinary bladder and the scattering coefficients of the top three layers (urothelium, lamina propria, and muscle layers, resp.) are extracted. An optical attenuation ratio of 1 : 6.2 : 4.2 for the three layers is reported.
Highlights
Bladder cancer is the fourth most common cancer among men
The current method for bladder cancer detection after the patient has reported symptoms that may be related to cancer is visual inspection of the bladder surface using endoscopic methods followed by biopsy
It is possible for cancerous and precancerous lesions to go undetected by urologists using conventional visual inspection
Summary
The current method for bladder cancer detection after the patient has reported symptoms that may be related to cancer is visual inspection of the bladder surface using endoscopic methods followed by biopsy. It is possible for cancerous and precancerous lesions to go undetected by urologists using conventional visual inspection. A sensitivity of 78% for bladder lesion detection using white light cystoscopy has been reported by Schmidbauer et al [1] Biopsies of these undetected cancer lesions are not taken because they are not visible to the urologist. Optical Coherence Tomography (OCT) has shown significant potential in this regard
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