Abstract
Arrays of microgrooves (width 6, 7, and 8 μm; depth 4.5μm; length 10, 20, 30, 40, and 100μm; number 2600 or 4704 in parallel) photofabricated in the surface of a single-crystal silicon substrate were converted to arrays of leak-proof microchannels by tightly covering them with an optically flat glass plate. Using the microchannels as a model of physiological capillaries, total flow rate of blood was determined under a constant suction while flow behavior of blood cells in each channel was microscopically observed. Erythrocyte deformability, leukocyte adhesiveness, and platelet aggregability quantified by channel transit time or channel blocking and reopening rates showed changes caused by environmental factors such as diet and exposure to bacterial cells.
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