Measurement and Thermodynamic Modeling of the Solubility of Lamotrigine, Deferiprone, Cefixime Trihydrate, and Cephalexin Monohydrate in Different Pure Solvents from 283.1 to 323.1 K

Abstract

The solubility of lamotrigine, deferiprone, cefixime trihydrate, and cephalexin monohydrate (pharmaceutical solutes) were measured in water, methanol, acetonitrile, and ethyl acetate from 283.1 to 323.1 K at atmospheric pressure. Cephalexin monohydrate was unstable and decomposed in ethyl acetate (even at 283.1 K), acetonitrile (at 303.1 K), and methanol (at 313.1 K). The experimental solubility data were correlated using the local composition models such as Wilson, nonrandom two-liquid theory (NRTL), universal quasichemical (UNIQUAC), and segment-based UNIQUAC (UNIQUAC-SAC). Moreover, the two temperature-dependent Buchowski-Ksiazaczak λh and modified Apelblat equations were applied to correlate the present data. The predicted solubility of the present studies using UNIQUAC-SAC model are compared with those have been given for the other solvents, so that one can conclude lamotrigine, deferiprone, cefixime trihydrate, and cephalexin monohydrate presented the highest solubility in acetic acid, acetic acid, ...