Measurement and thermodynamic modeling of solubility of Tamsulosin drug (anti cancer and anti-prostatic tumor activity) in supercritical carbon dioxide

Abstract

Among available methods, supercritical fluid (SCF) technology is a new and suitable approach for producing nano-sized particles. For this purpose, determination of a solid solute solubility such as pharmaceutical materials is an essential step. The present research is the first to measure Tamsulosin (TML) solubility in supercritical carbon dioxide (SC-CO2) under operating conditions of 308 to 338 K and 12 to 27 MPa. The mole fraction of TML ranged from 0.18 × 10−6 to 1.013 × 10−5. Experimental data have been modeled with two main models groups; the first group consisted of semi-empirical and empirical models (e.g., Chrastil; Sodeifian et al.; Kumar & Johnston (K-J); Méndez-Santiago & Teja (MST); Bian et al.; Bartle et al.) and the second group have been SAFT-VR (statistical associating fluid theory of variable range) and Peng-Robinson (PR) equations of state. Furthermore, self-consistency test of the experimental data was performed on the solubility data. Finally, the approximate values ΔHtotal, ΔHvap and ΔHsol enthalpies have been computed.