Experimental measurement and thermodynamic modeling of Lansoprazole solubility in supercritical carbon dioxide: Application of SAFT-VR EoS

Abstract

Solubility measurement of a solid solute in supercritical fluid (SCF) is considered as a primary step in micro- and nano-sized particles production through SCF technology. In this work, for the first time, solubility of Lansoprazole (LPZ) in supercritical carbon dioxide (SC–CO2) was determined at pressures and temperatures ranging within 12–27 MPa and 308.2–338.2 K, respectively. Under the applied conditions, mole fractions were obtained in the range of 1.15 × 10−5 to 7.36 × 10−4. For correlating the drug solubility, six semi-empirical models and two equations of state (EoSs), i.e., Peng–Robinson (PR) as a cubic EoS and SAFT-VR as a non-cubic EoSs were applied. Results showed the highest accuracy for “Reddy and Garlapati” model among semi-empirical models with AARDz of 7.36%. Furthermore, SAFT-VR EoS with AARD of 6.65 proved a very good priority than PR EoS and displayed the highest precision compared to all empirical models. This could be a promising application of SAFT equations to predict the thermodynamic behavior of SCFs.