MEASURE OF SERUM MDA, GST AND VIT-C IN WOMEN WITH CERVICAL CARCINOMA

Abstract

Cervical carcinoma (CaCx) is the second most common gynecological cancers globally. Many authors revealed that low levels of antioxidants induce the overproduction of reactive oxygen species (ROS) that result in oxidative stress. In the present study an attempt was made to evaluate the oxidative stress in 20 women with cervical carcinoma by measuring serum Malondialdehyde (MDA), Glutathione-S-transferase (GST) and Ascorbic acid (Vit-C) levels which was compared with 20 age matched non cancerous women. Signicantly elevated MDA levels (P<0.001) and lowered GST, Vit-C levels (P<0.0001) were observed in women with cervical carcinoma as compared with healthy controls. From our ndings it can be concluded that oxidative stress plays an important role in pathogenesis of cervical carcinoma. Hence supplementation of antioxidants may reduce the oxidative stress and minimize the associated morbidity and mortality