Assessment of serum levels of ascorbic acid and malondialdehyde as oxidative stress marker in patients with oral lichen planus

Abstract

Oral Lichen Planus (OLP) is a chronic inflammatory mucosal disease with unknown etiology. The cause might because of reactive oxygen species and oxidative damage to the tissues.In recent studies, free radicals have been postulated as the possible etiology of inflammatory and autoimmune disease.A total of 60 participants were studied and they were grouped in to cases and controls. Each group had 30 participants, 30 cases and 30 healthy controls. Serum levels of MDA and Vitamin C were estimatedThe data collected was analyzed statistically by using descriptive statistics namely mean, standard deviation and any significant difference between the mean values of cases and controls will be tested by using sample Student t-test. A p value ≤ 0.05 has been considered statistically significant. The present study was conducted to estimate the levels of Serum Ascorbic acid (vitamin C) and Malondialdehyde (MDA) levels, as biomarkers of oxidative stress in patients with oral lichen planus. The mean Serum Vitamin C levels in OLP patients and healthy controls were 2.5±0.46 mg/L and 9.28± 1.04 mg/L. The mean serum levels of MDA in OLP patients and healthy controls were 3.99±0.71nmol/mL and 1.39±0.20 nmol/ml.The current study demonstrates, existence of oxidative stress, compromised anti- oxidant defenses with higher levels of MDA and decreased levels of Vitamin C, in patients with oral lichen planus. Further studies are to be conducted to draw definite conclusion and significant correlation of the levels of the biomarkers in OLP.