Abstract
Introduction Immunotherapy works by increasing cell mediated immunity against HPV. Some studies have shown that combining immunomodulators with different MOA can result in a synergistic effect that is slightly better than single therapy. To compare the efcacy of Intralesional measles-rubella (MR) Aim & Objectives: vaccine with oral zinc VS IL MR vaccine monotherapy in treatment of palmoplantar warts In this hospital Materials and methods: based, interventional study, 20 clinically diagnosed cases of palmoplantar warts were enrolled and randomly divided into 2 groups of 10 patients each. Group A received 0.5 ml/2 units of MR vaccine, injected into the largest wart. The dose was repeated at 2-week intervals until complete clearance or maximum of 3 doses with oral zinc for one month. Group B received only 0.5ml/2 units of MR vaccine for the same period. Follow up was every 2 weeks for 3 months after last injection. Clinical improvement assessed by physician's global assessment using visual analogue scale score. Statistical analysis done using SPSSversion21. Results: In group A complete clearance in 60%, excellent response in 30%and good response in 10% , while in group B complete clearance in 50%,excellent response in 30% and good response in 20%.The mean number of injection for complete clearance 3.6 in group A & 3.8 in group B. No recurrence in either group. Clinical improvement slightly better in group A than in group B. Conclusion: In our study we found combination of two immunomodulators for the treatment of warts is slightly better than when used individually.
Published Version
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