Mean Platelet Volume as a Surrogate Marker of Long-Term Mortality in Patients Undergoing Percutaneous Coronary Intervention

Abstract

We have read the recently published article entitled “Usefulness of Mean Platelet Volume (MPV) as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention (PCI)” by Shah and coworkers. 1 Shah B. Oberweis B. Tummala L. Amoroso N.S. Lobach I. Sedlis S.P. Grossi E. Berger J.S. Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2013; 111: 185-189 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar In that very well-designed and presented study, Shah and coworkers tried to determine whether the preprocedural MPV or the change in MPV over time could be a predictor of long-term mortality in unselected patients undergoing PCI. They have shown a stronger association between an increase in the MPV over time and long-term mortality, even after multivariate adjustment. They suggested that serial assessments of MPV should be considered in evaluating prognosis. Mean Platelet Volume and Long-Term Mortality in Patients Undergoing Percutaneous Coronary InterventionAmerican Journal of CardiologyVol. 111Issue 2PreviewIncreased platelet activity is associated with adverse cardiovascular events. The mean platelet volume (MPV) correlates with platelet activity; however, the relation between the MPV and long-term mortality in patients undergoing percutaneous coronary intervention (PCI) is not well established. Furthermore, the role of change in the MPV over time has not been previously evaluated. We evaluated the MPV at baseline, 30 days, 60 days, 90 days, 1 year, 2 years, and 3 years after the procedure in 1,512 patients who underwent PCI. Full-Text PDF