Abstract
BackgroundPrevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Recently, a new estimator based on creatinine, the CKD-EPI equation, has been proposed which is presumed to better perform in normal GFR ranges. The aim of the study was to measure the difference in prevalence of stage 3 CKD in a population using either the MDRD or the CKD-EPI study equations.MethodsCKD screening is organized in the Province of Liège, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited to be screened. GFR is estimated by the MDRD study equation and by the "new" CKD-EPI equations.ResultsThe population screened consisted in 1992 people (47% of men). Mean serum creatinine was 0.86 ± 0.20 mg/dL. The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 11.04 and 7.98%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p < 0,0012).ConclusionsPrevalence of stage 3 CKD varies strongly following the method used for estimating GFR, MDRD or CKD-EPI study equations. Such discrepancies are of importance and must be confirmed and explained by additional studies using GFR measured with a reference method.
Highlights
Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study
Serum creatinine is of limited value for such a task, as it is classically known that creatinine will rise over normal values only when 50% of glomerular filtration rate (GFR) have already been lost [4,5]
We have evaluated if difference between equations might be correlated to variables such as age, sex, creatinine or estimated GFR levels
Summary
Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence of end-stage renal failure is increasing in Western Countries [1] even if this fact has been recently questioned [2] In this context, prevention of chronic kidney disease (CKD) is of importance [3]. Serum creatinine is of limited value for such a task, as it is classically known that creatinine will rise over normal values only when 50% of glomerular filtration rate (GFR) have already been lost [4,5]. This creatinine lack of sensitivity is especially due to its relationship with muscular mass and will be noted in population with lower muscular mass, notably the older population [4,6]. Several authors have proposed creatinine-based equation to According to these limitations, Levey's group who is already at the origin of the MDRD study equation has built a new creatinine-based equation from a large sam-
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