Abstract
Schistosomiasis is worldwide water-borne infectious risky disease. Steroid hormones are synthesizedfrom cholesterol in adrenal glands and gonads. They include corticosteroids, androgens,estrogens and progestogens. The present study evaluated the effect of Schistosoma mansoni andS. haematobium infections on the hamsters’ fertility as indicated by the changes of steroid sexhormones levels. Eighteen Mesocricetus auratus clear laboratory bred hamsters (9 males & 9females) were divided into 3 groups. G1: was infected with S. mansoni cercariae, G2: was infectedwith S. haematobium cercariae, and G3: was not infected (negative control). The resultsshowed that testosterone level increased in all infected hamsters but markedly increased in thoseinfected with schistosomiasis haematobium (7.52 & 0.78nmol/L) as compared to control (2.41 &0.341nmol/L). Progesterone level decreased in all infected hamsters especially in S. mansoni andS. haematobium females (5.732 & 11.13nmol/L) in comparison to control (86.34 &64.7nmol/L). Estradiol E2 level markedly decreased in female hamsters infected with either S.mansoni or S. haematobium (247.54 & 463.8pmol/L) as compared to control (1658pmol/L) butnot detected in male hamsters.
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