Abstract
Prenatal invasive tests are being used for the diagnosis of fetal aneuploidies. Fetal loss is the major complication of invasive procedures with varying proportions. In this prospective study, authors aimed to determine the predictivity of cervical length (CL) in terms of miscarriage associated with diagnostic prenatal invasive procedures that are performed in two separate centers.
Highlights
Appropriate fetal cells for karyotype analysis during pregnancy can be obtained from amniotic fluid by amniocentesis after 16 weeks of gestation, or from the placental tissue by chorionic villus sampling (CVS) in the first trimester, as well as from the fetal blood by cordocentesis at the advanced gestational ages
The distinct rate of pregnancy loss associated with amniocentesis is uncertain, but the American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin reported 1/300-500 risks of miscarriage associated with amniocentesis after the 15th week of pregnancy [1]
Amniocentesis was performed on 883 patients (83.9%) after 16 weeks gestation, CVS was carried out transabdominally on 93 patients (8.84%) between 11-14 weeks, and cordocentesis was performed on 76 patients (7.2%) (Table 2)
Summary
Appropriate fetal cells for karyotype analysis during pregnancy can be obtained from amniotic fluid by amniocentesis after 16 weeks of gestation, or from the placental tissue by chorionic villus sampling (CVS) in the first trimester, as well as from the fetal blood by cordocentesis at the advanced gestational ages. Several risk factors have been proposed for procedure-associated miscarriage such as operator experience, gestational age, sampling route, and the number of tapping; but the cause of procedure-related miscarriage remains unknown [5,6]. A short cervix, conventionally defined as shorter than 25 mm, obtained by transvaginal route in the mid-trimester of pregnancy, is a powerful risk factor for spontaneous preterm delivery. There is evidence that the measurement of the cervix at the 11-14 weeks scan can help to establish the risk of preterm birth [9,10]. Based on this data, it leads to the idea whether CL may predispose procedure-related miscarriage just as it predicts preterm birth
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