Abstract
In their study, Miller et al. separated both AD patients and controls into those with and without evidence of vascular disease and examined homocysteine levels. They found that elevated homocysteine was associated with patients (and controls) who had vascular disease but not specifically those diagnosed with AD. In contrast, low vitamin B6 status, which is seen with high homocysteine blood levels and which has been associated with poor memory in older adults was highly prevalent in the AD patients. The influence of homocysteine and B6 status on AD pathogenesis or progression remains to be determined. see page 1471 Sachdev et al. showed in their study of healthy elderly individuals that higher plasma homocysteine levels were related to brain atrophy as suggested by increased size of the lateral ventricles. see page 1539 Drazkowski …
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