Abstract
<p>The development of RMs was pioneered in the Philippines by the Industrial Technology Development Institute (ITDI) - DOST as part of its vision to establish metrological traceability and support the RMs needs of chemical testing laboratories in the country. Food safety issues for chemical testing of Philippine products were prioritized in this activity as these could affect the health of consumers and trade issues. Reference methods used for the provision of reference value was developed and validated for contaminants like histamine and benzoic acid in canned tuna and mango juice respectively. The materials were prepared and characterized and found to be homogeneous and stable for at least six (6) months. The reference value assigned to these RMs was done using a higher order method like isotope dilution technique coupled with Liquid Chromatography-Triple Quadrupole Mass Spectrometry (LCMSMS). Results were also cross-checked using gravimetric technique for High Performance Liquid Chromatography (HPLC) analysis. Certified RMs purchased from Metrology Institutes were also used to further support traceability of measurements. Philippine product RMs were developed for histamine and benzoic acid. The measurement traceability was disseminated by ITDI to local testing laboratories through the Proficiency Test schemes organized and conducted for the said analytes. </p>
Highlights
The need to ensure comparable and traceable chemical measurements is important for a country engaging in global trade
This study focused on the development of reference materials (RMs) for measuring histamine in canned tuna and benzoic acid in mango juice
The HPLC and Liquid chromatography-isotope dilution mass spectrometry (LC-IDMS) methods for benzoic acid and histamine with gravimetric sample preparation were validated, and the results are tabulated in Table 1 and Table 2, respectively
Summary
The need to ensure comparable and traceable chemical measurements is important for a country engaging in global trade. This need requires the establishment of a national chemical measurement organisation tasked with improving the capability for accurate measurements throughout the country. This study focused on the development of RMs for measuring histamine in canned tuna and benzoic acid in mango juice. These two chemicals are vital criteria for export food products as other countries have based their import approval decisions on the levels of these chemicals. Included in this study are homogeneity and stability studies, RM characterisation, and the process for conducting PT schemes for these substances
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