Abstract
Bone tissue pathology can generate irreversible defects that are not capable of regenerating by themselves. The current therapeutic approaches are based on native bone tissue grafts, either autologous or heterologous. However, these clinical approaches are commonly associated to morbidity, immunogenicity and availability. In this sense, Tissue Engineering allows, through the development of cellular constructs, a new therapeutic approach that aims to improve current ones. The specific properties of the bone tissue require an adequate selection of biomaterials used as a scaffold of the cellular construct as a bone substitute.
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