Mathematical Simulation of the Immunomodulating Role of Energy Metabolism in Support of Synergism and Antagonism of the Compartments of an Immune System

Abstract

The idea that pathology can be considered as the unity of two opposite processes — the degradation of intracellular structures which result in energy metabolism disturbance and the realization of some adaptive control mechanism, formed in the process of evolution, which support the values of vital parameters optimal for the present state of the organism — is one of the axioms of contemporary theoretical biology. When considering a pathological process from this viewpoint we may come to the conclusion that the problem of therapy is reduced to the definition of a set of actions which activate natural prevention mechanisms [3] of the organism and create an optimal condition for their realization. Mutual regulation of the processes of synthesis and consumption of energy in a cell occupy central places in the understanding of the activity of such molecular regulation mechanisms responsible for the adequate energy support of physiological functions of the organism. Without the study of this regulation we cannot understand and estimate properly the role of metabolic changes in a cell which accompany the various pathological processes and therefore we cannot choose properly a complex of therapeutic actions. The aim of the given paper is to investigate the role of energy metabolism in support of the balance of some branches of the immune system.