Abstract
A mathematical model was suggested to describe the process of biotransformation of methyl phenyl sulfide to ( R )-sulfoxide using immobilized cells Gordonia terrae IEGM 136. The experimental data were the base for determining kinetic regularities of the methyl phenyl sulfide biotransformation depending on the initial sulfide concentration and the biocatalyst quantity. The experimental data were compared to the results of mathematical modeling of scaling-up the process in a laboratory bioreactor. A mathematical model was developed to describe the said process with the re-used biocatalyst. The data obtained can be used for optimization of biotransformation of a wide range of organic alkylarylsulfides to produce optically active sulfoxides.
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