Abstract
BackgroundLymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts.MethodsA mathematical model of lymphatic filariaris with intervention strategies is developed and analyzed. Control of infections is analyzed within the model through medical treatment of infected-acute individuals and quarantine of infected-chronic individuals.ResultsWe derive the effective reproduction number, mathcal {R}_{0}, and its interpretation/investigation suggests that treatment contributes to a reduction in lymphatic filariasis cases faster than quarantine. However, this reduction is greater when the two intervention approaches are applied concurrently.ConclusionsNumerical simulations are carried out to monitor the dynamics of the filariasis model sub-populations for various parameter values of the associated reproduction threshold. Lastly, sensitivity analysis on key parameters that drive the disease dynamics is performed in order to identify their relative importance on the disease transmission.
Highlights
Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts
Lymphatic Filariasis commonly known as elephantiasis is a globally neglected tropical parasitic disease caused by a thread-like worms of the Filarioidea type (Wuchereria bancrofti, Brugia malayi and Brugia timori) [1]
1.4 billion people in 73 countries worldwide are threatened by the disease of which over 120 million individuals are currently infected [3]
Summary
Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts. Lymphatic Filariasis commonly known as elephantiasis is a globally neglected tropical parasitic disease caused by a thread-like worms of the Filarioidea type (Wuchereria bancrofti, Brugia malayi and Brugia timori) [1]. The most common of these, Wuchereria bancrofti, is a round worm that mainly infects the lymphatic system. Acute and chronic conditions with the majority of infections being asymptomatic [2]. The round worm (nematode) is spread from person to person via a mosquito vector and infected individuals can suffer from chronic conditions such as lymphedema, elephantiasis and, in men, swelling of the scrotum called hydrocele [1, 2].
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