Abstract
BackgroundMethylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of proteomic profile of parotid (PA), submandibular (SM), and sublingual (SL) glands of offspring rats.Materials and methodsPregnant Wistar rats were daily exposed to 40 μg/kg MeHg during both gestational and lactation periods. The proteomic profiles of the major salivary glands of the offspring rats were analyzed through mass spectrometry.ResultsThe offspring rats exposed to MeHg showed significant alterations in the proteomic profiles of the PA, SM, and SL glands. Altered proteins were associated with cytoskeleton components, tissue morphogenesis, and response to stimulus and stress.ConclusionThis original study showed that maternal MeHg exposure significantly modulates the expression of proteins and induces alterations in the proteomic profiles of developing salivary glands.
Highlights
Developing organisms are vulnerable to environmental toxins [1,2,3,4]
The offspring rats exposed to MeHg showed significant alterations in the proteomic profiles of the PA, SM, and SL glands
This original study showed that maternal MeHg exposure significantly modulates the expression of proteins and induces alterations in the proteomic profiles of developing salivary glands
Summary
Developing organisms are vulnerable to environmental toxins [1,2,3,4]. Methylmercury (MeHg) is a highly bioaccumulative toxic compound that remains a public health issue due to its natural and anthropogenic environmental distributions[4,5], such as soil erosion and biomass burning [6,7]. Our research group recently evidenced structural changes in the salivary glands of offspring rats after gestational and lactational MeHg exposure [11]. Methylmercury (MeHg) remains a public health issue since developing organisms are vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of proteomic profile of parotid (PA), submandibular (SM), and sublingual (SL) glands of offspring rats
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