Abstract
BackgroundGALNT2 is a GalNAc transferase that regulates serum lipid fractions, insulin signaling, and lipogenesis. Genetic variants are implicated in the pathogenesis of gestational diabetes mellitus (GDM). The objective of this study was to investigate the association of GALNT2 rs2144300 and rs4846914 single nucleotide polymorphisms (SNPs) with the risk of GDM and related traits.MethodsTwo SNPs were genotyped, and clinical and metabolic parameters were determined in 461 GDM patients and 626 control subjects. Genetic associations with related traits were also analyzed.ResultsThe genotype distributions of the two SNPs in GDM patients were similar to those in normal controls. However, significant differences were noted across the three groups of genotypes with respect to the examined variables in subjects in a BMI-dependent manner. The rs4846914 and rs2144300 SNPs of GALNT2 were significantly associated with systolic blood pressure and/or diastolic blood pressure levels in nonobese GDM patients and atherogenic index (AI) in overweight/obese GDM patients. The rs4846914 SNP was also associated with fetal growth in overweight/obese GDM patients, and apo A1 and pregnancy weight gain in overweight/obese control women (all P<0.05).ConclusionsThe two polymorphisms in the GALNT2 gene are associated with variations in blood pressure, atherogenic index, and fetal growth in GDM, depending on BMI, but not with GDM. Our findings highlight a link between related phenotypes in GDM mothers and their fetuses and the genetic components.
Highlights
Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy and is defined as any degree of glucose intolerance that begins or is first recognized during pregnancy [1]
Women with GDM had significantly higher fasting insulin and glucose concentrations, HOMA-IR, TG, TG/ high-density lipoprotein cholesterol (HDL-C) ratios, and lower low-density lipoprotein cholesterol (LDL-C) and apo A1 levels compared with the control women after adjusting for the difference in age and body mass index (BMI) at delivery (Table 1)
Genotypes of the rs2144300 and rs4846914 polymorphisms were in Hardy–Weinberg equilibrium in both GDM patients and control groups
Summary
Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy and is defined as any degree of glucose intolerance that begins or is first recognized during pregnancy [1]. GDM is associated with an increased risk of metabolic-related disorders, such as type 2 diabetes mellitus, metabolic syndrome, and cardiovascular events in future life [1, 3]. GDM might be related to genetic factors [4], dyslipidemia [5], oxidative stress [6], and inflammation [7]. Genetic variants are implicated in the pathogenesis of gestational diabetes mellitus (GDM). The objective of this study was to investigate the association of GALNT2 rs2144300 and rs4846914 single nucleotide polymorphisms (SNPs) with the risk of GDM and related traits
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