Maternal exposure to air pollution during pregnancy and cortisol level in cord blood

Abstract

Exposure to air pollution has been associated with disorders of the endocrine system and hypothalamic-pituitary-adrenal (HPA) axis; however, the available evidence on these associations is still scarce. This study aimed to investigate, for the first time, the association of exposure to PM1, PM2.5, and PM10, as well as traffic indicators (distance to major roads and total street length in different buffers around maternal residential address) during pregnancy with cortisol level in cord blood samples. This cross-sectional study was carried out based on 150 mother-newborn pairs in Sabzevar, Iran (2018). Land use regression models were applied to estimate air pollution exposure during the entire pregnancy at maternal residential addresses. Multiple linear regression models were applied to estimate the association of exposure to air pollution during pregnancy and cord blood cortisol levels, controlled for relevant covariates. There was a significant positive association between exposure to PM2.5 and PM10 and cortisol levels in cord blood (β = 2.55, 95% confidence intervals (CI) = 0.57, 4.52, P-value = 0.01, and β = 3.09, 95% CI: 1.28, 4.90, P-value < 0.01, respectively). Moreover, there was a significant positive association between total street length in a 100 m buffer around maternal residence and cortisol level. Each one interquartile range (IQR) increase in distance from home to major roads was associated with a −2.58 (95% CI: −4.85, −0.30, P-value = 0.03) decrease in cord blood cortisol level. The median (IQR) of the cord blood cortisol levels for the first and fourth quartiles of distance to major roads were 50.7 (19.5) and 38.2 (20.4) ng/mL, respectively. The associations for total street length in 300 m and 500 m buffers and PM1 exposure were not statistically significant. Our findings suggest a direct association of exposure to air pollution during pregnancy and cortisol levels at cord blood.