Abstract

Medical image segmentation is a fundamental task in medical image analysis. Dynamic receptive field is very helpful for accurate medical image segmentation, which needs to be further studied and utilized. In this paper, we propose Match Feature U-Net, a novel, symmetric encoder– decoder architecture with dynamic receptive field for medical image segmentation. We modify the Selective Kernel convolution (a module proposed in Selective Kernel Networks) by inserting a newly proposed Match operation, which makes similar features in different convolution branches have corresponding positions, and then we replace the U-Net’s convolution with the redesigned Selective Kernel convolution. This network is a combination of U-Net and improved Selective Kernel convolution. It inherits the advantages of simple structure and low parameter complexity of U-Net, and enhances the efficiency of dynamic receptive field in Selective Kernel convolution, making it an ideal model for medical image segmentation tasks which often have small training data and large changes in targets size. Compared with state-of-the-art segmentation methods, the number of parameters in Match Feature U-Net (2.65 M) is 34% of U-Net (7.76 M), 29% of UNet++ (9.04 M), and 9.1% of CE-Net (29 M). We evaluated the proposed architecture in four medical image segmentation tasks: nuclei segmentation in microscopy images, breast cancer cell segmentation, gland segmentation in colon histology images, and disc/cup segmentation. Our experimental results show that Match Feature U-Net achieves an average Mean Intersection over Union (MIoU) gain of 1.8, 1.45, and 2.82 points over U-Net, UNet++, and CE-Net, respectively.

Highlights

  • In the natural image task, various network structures have achieved satisfactory performance.Resnet [1], Mask-RCNN [2], and their derivative networks usually have hundreds of layers, or a large number of parameters

  • We present Match Feature U-Net (MFUnet), a U-Net-based architecture with a dynamic receptive field for medical image segmentation

  • We find that the performances of three networks (U-Net, UNet++, and CE-Net) using only adaptive receptive field mechanism are worse than that of the original networks and after introducing the Match operation, the performances are better than the original networks

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Summary

Introduction

In the natural image task, various network structures have achieved satisfactory performance. Resnet [1], Mask-RCNN [2], and their derivative networks usually have hundreds of layers, or a large number of parameters. The continuous improvement of hardware performance and large data sets such as ImageNet [3] make these complex large-scale networks very effective. The typical medical image segmentation model U-Net [4], which has a modest number of parameters, was trained end-to-end from very few images and outperforms the previous best method [5] (a sliding-window convolutional network) on the ISBI challenge for Symmetry 2020, 12, 1230; doi:10.3390/sym12081230 www.mdpi.com/journal/symmetry. Medical image data are so precious that large-scale networks are hard to train on small sample data sets. In the medical image segmentation task, the model should not have too many parameters.

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