Abstract
Dehydroepiandrosterone, androsterone and epiandrosterone sulphate and androsterone glucuronide were determined by mass fragmentography in pools of peripheral and portal venous plasma from postmenopausal women. Samples were analyzed both before and after oral administration of ampicillin for 4 days (2 g per day). The peripheral ketosteroid monosulphate concentrations were within the normal range for postmenopausal women reported in the literature. Androsterone glucuronide was present in concentrations of 42 μ/1 plasma. The peripheral and portal venous metabolite levels did not differ from each other either before or after ampicillin administration. With the exception of decreasing dehydroepiandrosterone sulphate levels ampicillin did not affect either portal or peripheral metabolite concentrations. The higher pre-ampicillin dehydroepiandrosterone sulphate concentrations may reflect a stress situation as the mean cortisol levels were also higher, but not significantly so in these samples.
Published Version
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