Abstract
Introduction Today Large-scale genome sequencing is filling up the catalogue of natural proteins at a breathtaking speed. Today, we have available not just a large number of sequences, but also glimpses of the inventory of entire organisms. This information will soon improve our understanding of cells and of life in general. Three means will contribute to this expanding body of knowledge: sequencing genomes (genomics); the determination of protein structures; and the determination of protein function. Protein structure is interwoven with function (e.g. [1–3]). Sequence analysis and determination of function are also routinely combined (e.g. [4]). What about the relationship between structure determination and genomics, however?
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