Marijuana use among adult liver transplant candidates and recipients.

Abstract

Data regarding marijuana (MJ) use among liver transplant (LT) candidates are limited. We set out to determine the incidence and pre- and post-LT outcomes of adult LT candidates with a self-reported history of MJ use. Baseline clinical characteristics, waitlist, and post-LT outcomes of adult LT candidates from January 2010 to March 2017 were compared. Among 2690 LT candidates, 630(23%) and 298(11%) reported a history of MJ use and use within the past 12months, respectively. Although the proportion of MJ users increased over time(β=.76, p=.03), the proportion listed and transplanted did not change. Listing for LT increased with male (OR 1.24, 95% CI 11.01-1.52), MELD score (OR 1.08, 95% CI 1.01-1.15), HCC (OR 1.83, 95% CI 1.39-2.41) but decreased among MJ users (OR 0.67, 95% CI 0.50-0.91, p=.01). The median time to listing was longer among MJ users compared to non-users (115 vs. 87days, p<.0005). Post-LT survival was similar in 83MJ users and 306 non-users. The proportion of MJ users among LT candidates is increasing. MJ users have a greater burden of psychosocial issues which may contribute to longer evaluations and lower rate of LT listing. Post-LT survival was not impacted by self-reported MJ use history.