Marcadores bioquímicos de cromosomopatía, pregnancy associated plasma proteína-A y fracción β de hormona gonadotropina coriónica humana, como predictores de alteraciones del crecimiento fetal

Abstract

ObjectiveThe principal aim of this study was to analyze the possible association between prenatal biochemical markers used in prenatal screening for aneuploidy, (pregnancy associated plasma protein A [PAPP-A] and beta-human chorionic gonadotropin) and low birth weight. MethodsWe performed a retrospective cohort study of patients who underwent first trimester screening for aneuploidies. The first and fifth percentiles in our population were calculated for each main variable. We used the chi-square test to assess the relationship between the distinct variables. ResultsA total of 987 patients were included. There were three stillbirths (0.3%) and 10 midtrimester miscarriages (1%). Of 974 live births, body weight was under the 10th percentile (p) in 84 (8.5%) and was under the third percentile in 21 (2.1%). There was a statistically significant association between low maternal serum PAPP-A and low birth weight. ConclusionOur results demonstrate that the biochemical markers used in prenatal screening for aneuploidy also predict low birth weight and can be used in clinical practice to provide an early diagnosis and improve the management of this entity.