Abstract
Radioisotope imaging is a powerful tool to understand the biological mechanisms in-vivo, especially in the brain of small animals, providing a significant model to study the human brain. In this context, we have developed and built a pixelated intracerebral positron probe to be embedded on awake and freely moving small animals, typically rats. This pixelated probe will represent a key instrument for neuroscientists to study neural mechanisms and correlate them to behavioral experiments. We describe in this paper the simulations carried out to design the intracerebral sensor, its architecture, and the detection of positrons in a volume with a couple of sensors assembled back-to-back. We also depict the architecture of the wireless acquisition system. Finally, we present the first measurements performed in real-time by this miniaturized probe with sealed radioactive sources and a 18F solution.
Highlights
In the context of understanding the brain function, which is altered by diseases such as Parkinson, Alzeimer or by addictions, the correlation of neural activity measurements with behavioral experiments is of major interest for biologists
Laniece and M-A Verdier are with the Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC), CNRS, Univ Paris Sud, Université Paris-Saclay, F-91406 Orsay, France
The probe flex connector is plugged in the corresponding male part with an interface board connected to the micro-controller printed circuit board (PCB)
Summary
In the context of understanding the brain function, which is altered by diseases such as Parkinson, Alzeimer or by addictions, the correlation of neural activity measurements with behavioral experiments is of major interest for biologists. Small animals constitute preclinical models for this study. Morel are with the Aix Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France. Laniece and M-A Verdier are with the Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC), CNRS, Univ Paris Sud, Université Paris-Saclay, F-91406 Orsay, France. Laniece and M-A Verdier are with Université de Paris, IMNC, F-91400 Orsay, France. Baudot are with the Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France. Zimmer are with the CERMEP-Imagerie du vivant, Université Claude Bernard Lyon 1, CNRS, INSERM, Hospices Civils de Lyon, Lyon, France. P. Gisquet-Verrier is with the NeuroPSI CNRS/INSB, Univ Paris Sud, Orsay, France
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