Abstract
Topoisomerases are enzymes that alter the topology of DNA. They play essential roles in resolving topological problems that arise in the genome during cellular processes such as transcription, replication, and chromosome segregation. Whereas both topological and sequence preferences of topoisomerases have been characterized, the interplay between these intrinsic properties of DNA in governing topoisomerase activity are not well understood. One category of topoisomerases, the Type II, functions through a strand passage mechanism, transiently cleaving a double stranded break to pass through another segment of DNA.
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