Abstract
action of DA at both or either population of receptors using the specific D1 and D2 antagonists, SCH-23390 and raclopride, respectively. Electrode microarrays chronically implanted in the dorsal striata of freely moving mice monitored changes in single unit and local field potential (LFP) activity following administration of the antagonists. The authors discriminated between the primary output neurons of the dorsal striatum, the medium spiny neurons (MSNs), and the fast-spiking interneurons and large aspiny neurons based upon the half-width, firing frequency, and ampli tude of the recorded waveforms. Single unit firing rate, relative power of differ ent frequency oscillations in the LFP, and entrainment of firing to the LFP (meas ured as spike-triggered average) were con
Highlights
A commentary on Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum by John M
D1-like and D2-like receptors have disparate patterns of expression and distinct physiological properties (Gerfen et al, 1990; Surmeier and Kitai, 1994; Taverna et al, 2008), and are expressed in separate neuronal populations involved in the basal ganglia direct pathway (D1) and indirect pathway (D2) (Albin et al, 1989; Alexander and Crutcher, 1990)
The authors discriminated between the primary output neurons of the dorsal striatum, the medium spiny neurons (MSNs), and the fast-spiking interneurons and large aspiny neurons based upon the half-width, firing frequency, and amplitude of the recorded waveforms
Summary
A commentary on Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum by John M. Depletion of DA leads to changes in neuronal firing rate and synchrony among cells in the dorsal striatum (Costa et al, 2006), but the role of direct and indirect pathways on these changes is yet unclear.
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