Abstract
Some antipsychotic drugs have treatment efficacy for mania and bipolar disorder. However, these drugs may rarely cause manic symptoms in some schizophrenic patients. We hereby report a 22-year-old female patient with schizophrenia who experienced a manic episode during a switch from paliperidone ER to paliperidone palmitate. This case is an important reminder that an abrupt switch from oral paliperidone to paliperidone palmitate may predispose certain patients to hypomanic or manic symptoms.
Highlights
Paliperidone is an antipsychotic agent which is the active metabolite of risperidone
This report presents a patient with schizophrenia who gradually developed manic symptoms after abruptly discontinuing oral paliperidone and beginning treatment with long-acting injectable paliperidone palmitate
Mania is attributed to the switching from oral paliperidone to paliperidone palmitate in this case because, based on extensive evaluations, there is no other plausible explanation
Summary
Paliperidone is an antipsychotic agent which is the active metabolite of risperidone. Paliperidone palmitate, a oncemonthly, long-acting injectable formulation of paliperidone, was recently marketed for the acute and maintenance treatment of schizophrenia in adults. Long-acting antipsychotics, such as paliperidone palmitate, procure continuous medication with a convenient dosing interval, aimed at enhancing treatment adherence in schizophrenic patients [1]. There are reports describing patients with manic symptoms associated with antipsychotic treatments [5]. We found only three case reports of mania associated with paliperidone treatment in the literature [6,7,8]. We here report a case with schizophrenia that experienced a manic episode during a switch from oral paliperidone to paliperidone palmitate
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
