Abstract

IntroductionVertical discrepancy between the fibula flap and the native mandible results in difficult prosthetic rehabilitation. The aim of this study was to evaluate the outcomes of 3D reconstruction of the mandible in oncologic patients using three different techniques through virtual surgical planning (VSP), cutting guides, customized titanium mesh and plates with CAD/CAM technology, STL models and intraoperative dynamic navigation for implant placement. Material and methodsMaterial and MethodsThree different techniques for mandibular reconstruction and implant rehabilitation were performed in 14 oncologic patients. Five patients (36%) underwent VSP, cutting guides, STL models and a customized double-barrel titanium plate with a double-barrel flap and immediate implants. In six patients (43%), VSP, STL models and a custom-made titanium mesh (CAD/CAM) for 3D reconstruction with iliac crest graft over a fibula flap with deferred dental implants were performed. Three patients (21%) underwent VSP with cutting guides and customized titanium plates for mandibular reconstruction and implant rehabilitation using intraoperative dynamic navigation was accomplished. Vertical bone reconstruction, peri-implant bone resorption, implant success rate, effects of radiotherapy in vertical reconstruction, bone resorption and implant failure, mastication, aesthetic result and dysphagia were evaluated.ResultsSignificant differences in bone growth between the double-barrel technique and iliac crest graft with titanium mesh technique were found (p<0.002). Regarding bone resorption, there were no significant differences between the techniques (p=0.11). 60 implants were placed with an osseointegration rate of 91.49%. Five implants were lost during the osseointegration period (8%). Peri-implant bone resorption was measured with a mean of 1.27 mm. There was no significant difference between the vertical gain technique used and implant survival (p>0.385). Implant survival rates were higher in non-irradiated patients (p<0.017). All patients were rehabilitated with a fixed implant-supported prosthesis reporting a regular diet (80%), normal swallowing (85.7%) and excellent aesthetic results.ConclusionsMulti-stage implementation of VSP, STL models and cutting guides, CAD/CAM technology, customized plates and in-house dynamic implant navigation for mandibular defects increases bone-to-bone contact, resolves vertical discrepancy and improves operative efficiency with reduced complication rates and minimal bone resorption. It provides accurate reconstruction that optimizes implant placement, thereby improving facial symmetry, aesthetics and function.

Highlights

  • Vertical discrepancy between the fibula flap and the native mandible results in difficult prosthetic rehabilitation

  • The inclusion criteria were: 1) oncologic patients with segmental mandibulectomy reconstructed through virtual surgical planning (VSP) with double-barrel fibula free flap, double-barrel customized plate and immediate implant placement with surgical guides; 2) oncologic patients with segmental mandibulectomy reconstructed with fibula flap and iliac crest graft with customized titanium mesh through VSP, CAD/ CAM technology and dental implants in a second surgical stage; 3) oncologic patients with segmental mandibulectomy reconstructed with fibula flap and implant rehabilitation through VSP and “in house” dynamic navigation in a second surgical procedure

  • In five patients (35%), mandibular reconstruction was performed in a single stage by means of VSP, double-barrel fibula flap, double-barrel customized titanium plate and immediate implant placement through surgical guides

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Summary

Introduction

Vertical discrepancy between the fibula flap and the native mandible results in difficult prosthetic rehabilitation. Mandibular defects in oncologic patients cause severe bone and soft tissue defects, with their consequent aesthetic and functional sequelae, and immediate mandibular reconstruction is mandatory. When resection is located on the body of the mandible, facial asymmetry is evident, with soft tissue collapse on the affected side [2,3,4]. If the tumor resection in the mandible includes the mandibular condyle, these sequelae are even more significant [1]. In addition to lip incompetence, other disabling functional sequelae include salivary incontinence, difficulty in chewing, swallowing, and speech articulation. Patients undergoing mandibular resection who do not receive reconstruction present progressive deviation and retrusion towards the affected side, increasing the functional sequelae exposed [1, 2]. Vertical masticatory movements are replaced by oblique and diagonal movements directed by a single temporomandibular joint which, added to the limited lingual mobility in many cases, increases the patient’s difficulties in social interaction

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