Managing platelets supply chain under uncertainty: A two-stage collaborative robust programming approach

Abstract

This study investigates the role of horizontal collaboration among blood centers in mitigating the negative impacts of fluctuations in blood platelet supply and demand during normal circumstances and after sudden-onset disasters. Specifically, four scenarios are studied: no collaboration, collaboration among blood centers, collaboration among hospitals, and collaboration among blood centers and hospitals. To formulate these scenarios, we propose a two-stage robust programming model that enables decision-makers to monitor the collaborative behavior of blood centers and hospitals before and after changes in supply and demand occur. In the first stage, a robust optimization approach is developed to cope with supply and demand uncertainties, where collaboration is limited to blood centers. In the second stage, the uncertain parameters (supply and demand) are treated as deterministic. The key decision is how to transfer platelets among hospitals located in a collaborative cluster. This research uses benchmark data from previous studies to test and validate the developed model and solution approach. Comparing the results obtained in different scenarios, we systematically select the most favorable scenario in terms of model performance under normal and emergency situations. The final results indicate that the network achieves the highest performance when blood centers and hospitals participate in the grand coalition.