Abstract
Thyroxine binding globulin (TBG) level increases during pregnancy due to the effects of oestrogen1. The increased TBG concentrations lead to elevation of the total thyroxine (T4) and triiodothyronine (T3) but not the free thyroxine (FT4) and free triiodothyronine (FT3) concentrations. This phenomenon is called euthyroid hyperthyroxinaemia and should be considered in interpreting the thyroid functions in pregnant women.
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