Abstract
Objective Mammary analog secretory carcinoma(MASC), is a distinctive low-grade malignant salivary cancer. Microscopically, most cases of MASC consist of a circumscribed mass divided by thin fibrous septa into lobules composed of microcystic, tubular, and solid structures. Due to the scarcity of reported cases, however, little information exists regarding this lesion in the salivary gland. Here, we report a case of MASC occurring in the parotid gland. Clinical Presentation Our patient is a 28-yer-old male who presented with a 3.0 × 2.5 × 2.0cm in the right parotid gland, referred slowly growing, painless approximately one year duration. The tumor is rubbery, with a white-tan to gray cut surface. On the cut surface of the mass, many small cystic spaces may be seen, containing yellow to whitish fluid. The borders of the tumor is circumscribed but not encapsulated. Conclusion Most cases of MASCs were diagnosed as AciCC or adenocarcinoma not otherwise specified. Many MASC were found to harbor an ETV6-NTRK3 fusion gene because of a t(12;15) (p13,q25) translocation, a finding identical to secretory carcinoma of the breast. The most recent version of the World Health Organization (WHO) Classification of Head and Neck Tumours utilizes the terminology of “secretory carcinoma” for consistency. In addition to the case report, we review the past and current cases enrolled of MASC. Awareness of such a clinical presentation is important for the clinician.
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