Abstract
Background Recent studies in canines have shown that focal iron depositions within chronic scar tissue influences the electrical behavior of infarcted hearts. Further, T2weighted CMR of post-mortem sudden cardiac death (SCD) victims with chronic myocardial infarction (CMI) have consistently demonstrated regions of signal loss within the CMI territories. To date, the link between the post-infarction iron depositions and malignant ventricular arrhythmias (mVA) in patients with CMI is not known. The aim of this study was to determine the incremental prognostic value of hypointense cores (HIC) identified within CMI using a potentially iron-sensitive CMR approach at 3.0T for the prediction of mVA.
Highlights
Recent studies in canines have shown that focal iron depositions within chronic scar tissue influences the electrical behavior of infarcted hearts
Primary endpoint was met in 19 patients with events occurring 343±269 days after ICD placement
In 19 patients meeting the primary endpoint, 18 were classified as positive for hypointense cores (HIC) (HIC+) while 1 subject was negative for HIC (HIC-)
Summary
Recent studies in canines have shown that focal iron depositions within chronic scar tissue influences the electrical behavior of infarcted hearts. T2weighted CMR of post-mortem sudden cardiac death (SCD) victims with chronic myocardial infarction (CMI) have consistently demonstrated regions of signal loss within the CMI territories. The link between the post-infarction iron depositions and malignant ventricular arrhythmias (mVA) in patients with CMI is not known. The aim of this study was to determine the incremental prognostic value of hypointense cores (HIC) identified within CMI using a potentially iron-sensitive CMR approach at 3.0T for the prediction of mVA
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