Malignant peripheral nerve sheath tumour in a sow

Talita P Resende,Geovanni D Cassali,José Lúcio Dos Santos,Fabio A Vannucci,Fernando S Araujo,Roberto M C Guedes,Karine A Damasceno,Carlos E R Pereira

doi:10.1186/s13028-015-0150-y

Talita P Resende, Geovanni D Cassali + Show 6 more

Open Access

https://doi.org/10.1186/s13028-015-0150-y

Copy DOI

Abstract

Nodular lung lesions in swine are frequently due to abscesses or granulomatous pneumonia. Although tumours are rarely reported in modern pig farming, they should be considered as a differential diagnosis when nodular lung lesions are found. A first-parity sow exhibiting respiratory signs was euthanized. Several whitish firm nodules, not encapsulated, ranging in diameter from 0.5 to 5 cm were present in all lung lobes. Microscopically, the nodules were composed of dense neoplastic cells, mainly in Antoni types A and B patterns, infiltrative and with development of emboli. All neoplastic cells stained positively by immunohistochemistry for vimentin and S-100 protein, with variable immunostaining for glial fibrillary acidic protein and stained negative for cytokeratin. Based on the gross, histological and immunohistochemical features, the tumor was diagnosed as malignant peripheral nerve sheath tumour.

Highlights

Gross nodular lung lesions in pigs are frequently associated with abscesses [1] or granulomatous pneumonia [2] but may be caused by other conditions such as neoplasms
Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270‐901, Brazil Full list of author information is available at the end of the article immunohistochemical findings in a case of a porcine pulmonary malignant peripheral nerve sheath tumor (MPNST)
Staining for glial fibrillary acid protein (GFAP) showed variable immunostaining in the neoplastic cells, i.e. weak and sparse in Antoni type B patterns and moderate to strong in spindle-shaped cells from the Antoni type A patterns, including intravascular located neoplastic cells (Fig. 2)

Summary

Introduction

Gross nodular lung lesions in pigs are frequently associated with abscesses [1] or granulomatous pneumonia [2] but may be caused by other conditions such as neoplasms. Malignant peripheral nerve sheath tumours (MPNSTs) (former “schwannomas”) are relatively common in humans [4] and cattle [5] but rarely reported in other species [6]. *Correspondence: guedesufmg@gmail.com 1 Department of Veterinary Clinic and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270‐901, Brazil Full list of author information is available at the end of the article immunohistochemical findings in a case of a porcine pulmonary MPNST.

Results

Conclusion