Abstract
Background: The relation of ovarian induction drugs to development of ovarian cancer is still unclear. Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that has been reported as a risk factor for ovarian cancer in some studies. Case presentation: We report two cases with polycystic ovarian syndrome who developed a malignant ovarian dysgerminoma following use of ovulation induction drugs. One of them was diagnosed during fifth month of pregnancy by intracytoplasmic injection (ICSI). Both cases were treated with conservative surgery. Conclusion: We reported 2 cases of ovarian dysgerminoma in patients with PCOS following ovarian stimulation. A large multicenter observational study is recommended to investigate a possible association.
Highlights
The relation of ovarian induction drugs to development of ovarian cancer is still unclear
Case presentation: We report two cases with polycystic ovarian syndrome who developed a malignant ovarian dysgerminoma following use of ovulation induction drugs
We reported 2 cases of ovarian dysgerminoma in patients with Polycystic ovary syndrome (PCOS) following ovarian stimulation
Summary
There is increasing use of fertility medications for ovulation induction and ovarian stimulation for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in the treatment of female infertility. A 23 years old female complained of primary infertility for 5 years because of polycystic ovarian syndrome (PCOS) Her husband had normal semen analysis and other fertility factors were normal. The course of pregnancy was normal till the twenty-second week where a solid right ovarian mass 5X5 cm accidentally discovered during routine ultrasound scanning with no ascites and other abdominal organs were normal (Figure 1). According to tumor board recommendations the patient was advised to receive 4 courses of BEP (Bleomycine, Etopozide, Cisplatinum) chemotherapy as an adjuvant treatment Her post-operative follow-up by CT scans and tumor markers at 3, 6, and 12 months was normal. One year later; the patient lost to follow up and her reproductive outcome was not known
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