Abstract
Introduction: Mucosal melanoma of the nasal cavity is a rare tumor. It is seen more commonly in the elderly and is known to have a male preponderance. Patients often present with non-specific symptoms of nasal obstruction or epistaxis. these tumors carry a poor prognosis because of higher rates of locoregional recurrence and distant metastasis. case r eport: We report a 54-year-old male who presented with submandibular swelling and history of episodes of occasional epistaxis. Microscopic examination of the excision biopsy of the submandibular lymph node supported with immunohistochemistry (IHc) was suggestive of metastatic deposit of malignant melanoma. clinical examination and radiological imaging for the primary tumor lead to detection of a mass in the right nasal cavity. Histopathology of
Highlights
Mucosal melanoma of the nasal cavity is a rare tumor
Case Report: We report a 54-year-old male who presented with submandibular swelling and history of episodes of occasional epistaxis
Malignant melanomas can mimic a large number of malignant diseases and early diagnosis by astute pathologist can help achieve attain long time remission
Summary
Melanomas are tumors arising from melanocytes which are neural crest derived cells present in the basal layer of skin, hair follicles, most squamous-covered mucosal membranes, leptomeninges and several other sites [1]. The patient, noticed a gradual increase in the size of the swelling without overlying skin changes He complained of occasional episodes of bleeding from right nostril. He underwent fine-needle aspiration cytology (FNAC) of the right submandibular swelling in a local peripheral hospital which was reported as suggestive of nonHodgkin lymphoma He was referred to our tertiary care centre for further treatment and management. The patient underwent excision biopsy of the submandibular swelling and histopathological examination showed effacement of entire lymph node architecture by a tumor composed of sheets of polygonal cells having high N:C ratio, variable amount of cytoplasm, coarse vesicular chromatin and prominent eosinophilic nucleoli. Based on HPE and IHC the diagnosis of malignant melanoma was offered (Figure 2A–C) This tumor was considered as primary melanoma of nasal cavity due to the absence of previous or concurrent pigmented lesions elsewhere. One year after the diagnosis the patient is disease free and is on regular follow-up at our hospital
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