Abstract
Pubertal changes generally commence in males between 9.8 and 14.2 years with a mean of 11.8 years. Although there are a number of diseases that can lead to delayed puberty in males the vast majority of boys who experience delayed puberty have no underlying clinical pathologic condition. In a large case series of patients with delayed puberty 63% of males were found to have a constitutional delay. Of the remaining males with delayed puberty 19% had functional hypogonadotropic hypogonadism (FHH) and went into spontaneous pubertal development albeit late. Conditions leading to FHH in males included growth hormone deficiency hypothyroidism Crohns disease celiac disease sickle cell anemia seizure disorders and severe asthma. Males are much less likely than females to have a clinical pathologic condition as a basis of delayed onset of puberty; in fact most boys who enter puberty late have a family history of delayed pubertal development. (excerpt)
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