Making sense of p53 isoforms

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The tumour suppressor, p53, has been classified as a ‘guardian of the genome’, due to its ability to coordinate multiple signalling pathways involved in the DNA damage response including the induction of cell cycle arrest and DNA repair or apoptosis. The importance of p53 in tumour suppression has long been established, with mutations arising in more than half of all human cancers. p53 has clear prognostic power where its somatic mutation is associated with tumour progression, resistance to therapy and poor prognosis.