Abstract
Canine vector-borne diseases (CVBDs) are of major socioeconomic importance worldwide. Although many studies have provided insights into CVBDs, there has been limited exploration of fundamental molecular aspects of most pathogens, their vectors, pathogen-host relationships and disease and drug resistance using advanced, 'omic technologies. The aim of the present article is to take a prospective view of the impact that next-generation, 'omics technologies could have, with an emphasis on describing the principles of transcriptomic/genomic sequencing as well as bioinformatic technologies and their implications in both fundamental and applied areas of CVBD research. Tackling key biological questions employing these technologies will provide a 'systems biology' context and could lead to radically new intervention and management strategies against CVBDs.
Highlights
Difficult to estimate, the impact of canine vector-borne diseases (CVBDs) to dog and human populations is substantial [1,2,3]
Concluding remarks Vector-borne diseases, of which CVBDs represent a substantial component, represent ~17% of the burden of all infectious diseases and have a major socioeconomic impact worldwide [130]. In addition to their veterinary importance, some CVBD-causing agents are of major zoonotic importance
Various studies have provided improved insights into the epidemiology of CVBDs using molecular methods, there has been limited study of fundamental molecular aspects of many pathogens, their vectors, pathogen-host relationships and disease as well as drug or insecticide resistance using some of the advanced ‘omic technologies described here
Summary
The impact of canine vector-borne diseases (CVBDs) to dog and human populations is substantial [1,2,3]. This workflow system has proved very useful for timeefficient and accurate analyses of large-scale transcriptomic datasets generated by NGS and for distilling biologically meaningful information (such as predictions of essential molecules) on the parasite, the vector or the host under investigation Exciting prospects in both fundamental and applied areas Knowledge of the transcriptomes and proteomes of different developmental stages of a parasite, its vector and its definitive host is central to gaining an enhanced understanding of the molecular mechanisms that govern essential biological, infection and disease processes and, could assist in identifying possible avenues for the development of novel intervention strategies. An integrated use of ‘omic technologies will pave the way to a better understanding of the systems biology of CVBDs on a scale never before possible, and, hopefully, will provide golden opportunities for the development of entirely new intervention strategies in public-private partnerships
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